This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages) The topic of this article may not meet Wikipedia's general notability guideline. Please help to demonstrate the notability of the topic by citing reliable secondary sources that are independent of the topic and provide significant coverage of it beyond a mere trivial mention. If notability cannot be shown, the article is likely to be merged, redirected, or deleted.Find sources: "6-Hydroxykynurenic acid" – news · newspapers · books · scholar · JSTOR (June 2022) (Learn how and when to remove this template message) This article provides insufficient context for those unfamiliar with the subject. Please help improve the article by providing more context for the reader. (June 2022) (Learn how and when to remove this template message) (Learn how and when to remove this template message)
6-Hydroxykynurenic acid
Names
Preferred IUPAC name
4,6-Dihydroxyquinoline-2-carboxylic acid
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C10H7NO4/c12-5-1-2-7-6(3-5)9(13)4-8(11-7)10(14)15/h1-4,12H,(H,11,13)(H,14,15)
    Key: CQUUHDQRJWXDPY-UHFFFAOYSA-N
  • InChI=1/C10H7NO4/c12-5-1-2-7-6(3-5)9(13)4-8(11-7)10(14)15/h1-4,12H,(H,11,13)(H,14,15)
    Key: CQUUHDQRJWXDPY-UHFFFAOYAS
  • C1=CC2=C(C=C1O)C(=CC(=N2)C(=O)O)O
Properties
C10H7NO4
Molar mass 205.169 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

6-Hydroxykynurenic acid is a constituent of ginkgo and an amino acid.[1] It is a derivative of kynurenic acid and has similarly been found to antagonize AMPA and NMDA, as well as their corresponding receptors.[2]

See also

References

  1. ^ van Beek, Teris A (2002-08-16). "Chemical analysis of Ginkgo biloba leaves and extracts". Journal of Chromatography A. Chromatographic and Electrophoretic Analysis of Secondary Metabolites of Plants. 967 (1): 21–55. doi:10.1016/S0021-9673(02)00172-3. ISSN 0021-9673. PMID 12219929.
  2. ^ Weber, Marco; Dietrich, Dirk; Gräsel, Ines; Reuter, Gerhard; Seifert, Gerald; Steinhäuser, Christian (2001-12-20). "6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones: 6-Hydroxykynurenate blocks glutamate receptors". Journal of Neurochemistry. 77 (4): 1108–1115. doi:10.1046/j.1471-4159.2001.00340.x. PMID 11359876. S2CID 23178914.


Categories