RPLP1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2LBF, 4BEH, 4V6X,%%s4V6X, 4BEH
Identifiers
Aliases	RPLP1, LP1, P1, RPP1, ribosomal protein lateral stalk subunit P1
External IDs	OMIM: 180520 HomoloGene: 133573 GeneCards: RPLP1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 69,452,814 bp[1] End 69,456,205 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus trachea synovial membrane quadriceps femoris muscle spinal ganglia vastus lateralis muscle bone marrow cells skin of abdomen skeletal muscle tissue ascending aorta n/a More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding protein kinase activator activity ribonucleoprotein complex binding Cellular component cytosol ribosome focal adhesion intracellular anatomical structure cytosolic large ribosomal subunit extracellular exosome Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay translational elongation activation of protein kinase activity cytoplasmic translation positive regulation of protein kinase activity protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6176 n/a Ensembl ENSG00000137818 n/a UniProt P05386 n/a RefSeq (mRNA) NM_213725 NM_001003 n/a RefSeq (protein) NP_000994 NP_998890 NP_000994.1 n/a Location (UCSC) Chr 15: 69.45 – 69.46 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

60S acidic ribosomal protein P1 is a protein that in humans is encoded by the RPLP1 gene.^[3]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the Escherichia coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

Interactions

RPLP1 has been shown to interact with RPLP2.^[4]