RPLP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S4J, 2JDL, 2LBF, 2W1O, 4BEH, 4V6X
Identifiers
Aliases	RPLP2, D11S2243E, LP2, P2, RPP2, ribosomal protein lateral stalk subunit P2
External IDs	OMIM: 180530 MGI: 1914436 HomoloGene: 133574 GeneCards: RPLP2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 809,965 bp[1] End 812,880 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple abdominal fat lower lobe of lung superficial temporal artery peritoneum pericardium urethra thymus pylorus human penis n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein binding Cellular component cytosol ribosome membrane focal adhesion intracellular anatomical structure cytosolic large ribosomal subunit extracellular exosome synapse Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cytoplasmic translation translational elongation protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6181 67186 Ensembl ENSG00000177600 ENSMUSG00000025508 UniProt P05387 P99027 RefSeq (mRNA) NM_001004 NM_026020 NM_001360657 NM_001360658 RefSeq (protein) NP_000995 NP_080296 NP_001347586 NP_001347587 Location (UCSC) Chr 11: 0.81 – 0.81 Mb n/a PubMed search [2] [3]
Wikidata
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60S acidic ribosomal protein P2 is a protein that in humans is encoded by the RPLP2 gene.^[4][5]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the Escherichia coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[5]

Interactions

RPLP2 has been shown to interact with RPLP1.^[6]