RPL11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 4XXB, 5AJ0, 4V5Z, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC,%%s4UJE, 4XXB, 4UJD, 4D67, 4V5Z, 4V6X, 5AJ0, 4UJC, 4D5Y, 4UG0
Identifiers
Aliases	RPL11, DBA7, GIG34, L11, ribosomal protein L11, uL5
External IDs	OMIM: 604175 MGI: 1914275 HomoloGene: 37376 GeneCards: RPL11
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 23,691,742 bp[1] End 23,696,835 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 135,755,576 bp[2] End 135,780,739 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence monocyte right lung body of stomach lymph node Achilles tendon canal of the cervix right uterine tube rectum peritoneum Top expressed in yolk sac lip morula superior frontal gyrus spermatid spermatocyte thymus neural tube proximal tubule esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function rRNA binding protein binding RNA binding structural constituent of ribosome 5S rRNA binding ubiquitin protein ligase binding ubiquitin ligase inhibitor activity Cellular component cytosol ribosome membrane intracellular anatomical structure nucleolus cytosolic large ribosomal subunit extracellular exosome nucleus extracellular matrix nucleoplasm cytoplasm protein-containing complex polysomal ribosome Biological process protein targeting viral transcription SRP-dependent cotranslational protein targeting to membrane ribosomal large subunit biogenesis translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis ribosomal large subunit assembly positive regulation of gene expression positive regulation of protein binding protein stabilization negative regulation of ubiquitin protein ligase activity negative regulation of ubiquitin-dependent protein catabolic process negative regulation of protein neddylation regulation of signal transduction by p53 class mediator negative regulation of proteasomal ubiquitin-dependent protein catabolic process protein localization to nucleus positive regulation of signal transduction by p53 class mediator positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6135 67025 Ensembl ENSG00000142676 ENSMUSG00000059291 UniProt P62913 Q5VVD0 Q9CXW4 RefSeq (mRNA) NM_001199802 NM_000975 NM_025919 RefSeq (protein) NP_000966 NP_001186731 NP_000966.2 NP_080195 Location (UCSC) Chr 1: 23.69 – 23.7 Mb Chr 4: 135.76 – 135.78 Mb PubMed search [3] [4]
Wikidata
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60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene.^[5][6]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternative splice variants encoding different isoforms may exist, but they have not been fully characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^{[citation needed]}

Interactions

RPL11 has been shown to interact with:

• BLMH,^[7]
• Mdm2,^[8][9]
• NOP53,^[10]
• P16,^[8]
• P53,^[8] and
• Promyelocytic leukemia protein^[11]