RPL12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V6X, 5AJ0, 3J92, 4V5Z, 5A8L
Identifiers
Aliases	RPL12, L12, ribosomal protein L12
External IDs	OMIM: 180475 MGI: 98002 HomoloGene: 128047 GeneCards: RPL12
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.3 Start 127,447,674 bp[1] End 127,451,406 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 32,851,571 bp[2] End 32,855,357 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon uterine tube canal of the cervix skin of abdomen gallbladder lymph node smooth muscle tissue right coronary artery rectum thyroid gland Top expressed in yolk sac esophagus ileum uterus morula lens zone of skin bone marrow blastocyst quadriceps femoris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural constituent of ribosome rRNA binding RNA binding large ribosomal subunit rRNA binding Cellular component cytosol extracellular exosome membrane cytosolic large ribosomal subunit focal adhesion ribosome extracellular matrix nucleus nucleolus cytoplasm postsynaptic density large ribosomal subunit Biological process translational initiation SRP-dependent cotranslational protein targeting to membrane nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ribosomal large subunit assembly viral transcription protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6136 269261 Ensembl ENSG00000197958 ENSMUSG00000038900 UniProt P30050 P35979 RefSeq (mRNA) NM_000976 NM_009076 RefSeq (protein) NP_000967 NP_033102 Location (UCSC) Chr 9: 127.45 – 127.45 Mb Chr 2: 32.85 – 32.86 Mb PubMed search [3] [4]
Wikidata
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60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene.^[5][6]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]

Interactions

RPL12 has been shown to interact with CDC5L.^[7]