RPL28
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AJ0, 4UG0, 4V6X, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL28, L28, ribosomal protein L28
External IDs	OMIM: 603638 MGI: 101839 HomoloGene: 768 GeneCards: RPL28
EC number	3.6.5.3
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,385,932 bp[1] End 55,403,250 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A1|7 2.77 cM Start 4,795,873 bp[2] End 4,798,065 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superficial temporal artery cavity of mouth spongy bone lower lobe of lung human penis caput epididymis corpus epididymis vulva stromal cell of endometrium right uterine tube Top expressed in urinary bladder yolk sac adrenal gland white adipose tissue bone marrow uterus thymus spleen ganglionic eminence islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding structural constituent of ribosome Cellular component cell body cytosol ribosome membrane intracellular anatomical structure dendrite cytoplasmic ribonucleoprotein granule cytosolic large ribosomal subunit extracellular exosome Biological process positive regulation of protein targeting to mitochondrion viral transcription SRP-dependent cotranslational protein targeting to membrane regulation of autophagy of mitochondrion translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6158 19943 Ensembl ENSG00000108107 ENSMUSG00000030432 UniProt P46779 P41105 RefSeq (mRNA) NM_000991 NM_001136134 NM_001136135 NM_001136136 NM_001136137 NM_001363697 NM_009081 RefSeq (protein) NP_000982 NP_001129606 NP_001129607 NP_001129608 NP_001129609 NP_001350626 NP_033107 Location (UCSC) Chr 19: 55.39 – 55.4 Mb Chr 7: 4.8 – 4.8 Mb PubMed search [3] [4]
Wikidata
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60S ribosomal protein L28 is a protein that in humans is encoded by the RPL28 gene.^[5][6][7]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]