RPL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0
Identifiers
Aliases	RPL3, ASC-1, L3, TARBP-B, ribosomal protein L3
External IDs	OMIM: 604163 MGI: 1351605 HomoloGene: 747 GeneCards: RPL3
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 39,312,882 bp[1] End 39,320,389 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 79,961,992 bp[2] End 79,976,069 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary canal of the cervix stromal cell of endometrium ganglionic eminence right uterine tube skin of abdomen left uterine tube right lobe of thyroid gland gastric mucosa cerebellar hemisphere Top expressed in ovary hypothalamus ganglionic eminence lens zone of skin hippocampus proper uterus urinary bladder blastocyst pancreas More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding 5S rRNA binding RNA binding structural constituent of ribosome Cellular component ribosome focal adhesion intracellular anatomical structure extracellular exosome nucleolus nucleus cytoplasm cytosolic large ribosomal subunit cytosol protein-containing complex synapse Biological process cellular response to interleukin-4 viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing ribosomal large subunit assembly protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6122 27367 Ensembl ENSG00000100316 ENSMUSG00000060036 UniProt P39023 P27659 RefSeq (mRNA) NM_001033853 NM_000967 NM_013762 RefSeq (protein) NP_000958 NP_001029025 NP_038790 Location (UCSC) Chr 22: 39.31 – 39.32 Mb Chr 15: 79.96 – 79.98 Mb PubMed search [3] [4]
Wikidata
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60S ribosomal protein L3 is a protein that in humans is encoded by the RPL3 gene.^[5][6][7]

Function

Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. The RPL3 gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]