RPL31
Identifiers
Aliases	RPL31, L31, ribosomal protein L31
External IDs	OMIM: 617415 MGI: 2149632 HomoloGene: 133014 GeneCards: RPL31
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2 Start 101,002,229 bp[1] End 101,024,032 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 39,406,923 bp[2] End 39,410,992 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caput epididymis spongy bone vulva corpus epididymis germinal epithelium lactiferous duct human penis Achilles tendon pericardium vena cava Top expressed in yolk sac superior frontal gyrus lip morula fossa Paneth cell primitive streak condyle ureter ectoderm More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome Cellular component ribosome intracellular anatomical structure Biological process protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6160 114641 Ensembl ENSG00000071082 ENSMUSG00000073702 UniProt H7C2W9 P62900 RefSeq (mRNA) NM_001099693 NM_000993 NM_001098577 NM_001252218 NM_001252219 NM_053257 RefSeq (protein) n/a NP_001239147 NP_001239148 NP_444487 Location (UCSC) Chr 2: 101 – 101.02 Mb Chr 1: 39.41 – 39.41 Mb PubMed search [3] [4]
Wikidata
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60S ribosomal protein L31 is a protein that in humans is encoded by the RPL31 gene.^[5][6][7]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

Interactions

RPL31 has been shown to interact with BRCA1.^[8]