RPL34
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J7R, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL34, L34, ribosomal protein L34
External IDs	OMIM: 616862 MGI: 3648994 HomoloGene: 137646 GeneCards: RPL34
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q25 Start 108,620,569 bp[1] End 108,630,412 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caput epididymis corpus epididymis Achilles tendon lactiferous duct optic nerve mucosa of urinary bladder ganglionic eminence superficial temporal artery lower lobe of lung synovial membrane n/a More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding structural constituent of ribosome cadherin binding Cellular component cytosol ribosome intracellular anatomical structure mitochondrion cytosolic large ribosomal subunit extracellular exosome cytoplasm endoplasmic reticulum Biological process ribosome biogenesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6164 623174 Ensembl ENSG00000109475 ENSMUSG00000061669 UniProt P49207 n/a RefSeq (mRNA) NM_000995 NM_033625 NM_001319232 NM_001319234 NM_001319235 NM_001319236 n/a RefSeq (protein) NP_000986 NP_001306161 NP_001306163 NP_001306164 NP_001306165 NP_296374 n/a Location (UCSC) Chr 4: 108.62 – 108.63 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L34 is a protein that in humans is encoded by the RPL34 gene.^[4][5][6]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Transcript variants derived from alternative splicing, alternative transcription initiation sites, and/or alternative polyadenylation exist; these variants encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]