RPL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL5, DBA6, L5, PPP1R135, MSTP030, Ribosomal protein L5, uL18
External IDs	OMIM: 603634 MGI: 102854 HomoloGene: 110649 GeneCards: RPL5
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.1 Start 92,832,013 bp[1] End 92,841,924 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 52.23 cM Start 108,048,368 bp[2] End 108,056,871 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium parietal pleura tibia palpebral conjunctiva ganglionic eminence lower lobe of lung anterior pituitary lactiferous duct Achilles tendon canal of the cervix Top expressed in uterus ovary ganglionic eminence lens spermatocyte ileum esophagus zone of skin morula thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function rRNA binding protein binding RNA binding structural constituent of ribosome mRNA 3'-UTR binding 5S rRNA binding ubiquitin protein ligase binding mRNA 5'-UTR binding ubiquitin ligase inhibitor activity Cellular component cytoplasm cytosol ribosome membrane focal adhesion intracellular anatomical structure nucleolus cytosolic large ribosomal subunit extracellular exosome nucleus nucleoplasm endoplasmic reticulum protein-containing complex synapse ribonucleoprotein complex Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane ribosomal large subunit biogenesis translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing ribosomal large subunit assembly protein biosynthesis positive regulation of gene expression positive regulation of translation protein stabilization negative regulation of ubiquitin protein ligase activity negative regulation of ubiquitin-dependent protein catabolic process negative regulation of protein neddylation regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6125 100503670 Ensembl ENSG00000122406 ENSMUSG00000058558 UniProt P46777 Q5T7N0 P47962 RefSeq (mRNA) NM_000969 NM_016980 RefSeq (protein) NP_000960 NP_058676 Location (UCSC) Chr 1: 92.83 – 92.84 Mb Chr 5: 108.05 – 108.06 Mb PubMed search [3] [4]
Wikidata
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60S ribosomal protein L5 is a protein that in humans is encoded by the RPL5 gene.^[5][6]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase 2.

Clinical significance

Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

Interactions

Ribosomal protein L5 has been shown to interact with:

• CSNK2B,^{[8][9][10][11]}
• EIF5A,^[12]
• Mdm2,^[13][14][15] and
• PDCD4.^[16]