RPL7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0
Identifiers
Aliases	RPL7, L7, humL7-1, ribosomal protein L7, ribosomal protein uL30
External IDs	OMIM: 604166 MGI: 98073 HomoloGene: 87772 GeneCards: RPL7
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.11 Start 73,290,242 bp[1] End 73,295,789 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A3 Start 16,171,519 bp[2] End 16,174,886 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon gastric mucosa canal of the cervix monocyte smooth muscle tissue skin of abdomen rectum left uterine tube right uterine tube Top expressed in ganglionic eminence blastocyst uterus zone of skin lens morula esophagus thymus bone marrow ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein homodimerization activity DNA binding mRNA binding RNA binding structural constituent of ribosome Cellular component ribosome nucleolus cytoplasm cytosol nucleus membrane focal adhesion extracellular exosome polysome cytosolic large ribosomal subunit postsynaptic density ribonucleoprotein complex Biological process SRP-dependent cotranslational protein targeting to membrane maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) viral transcription nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cytoplasmic translation ribosomal large subunit biogenesis translational initiation protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6129 19989 Ensembl ENSG00000147604 ENSMUSG00000043716 UniProt P18124 P14148 RefSeq (mRNA) NM_000971 NM_001363737 NM_011291 RefSeq (protein) NP_000962 NP_001350666 NP_035421 Location (UCSC) Chr 8: 73.29 – 73.3 Mb Chr 1: 16.17 – 16.17 Mb PubMed search [3] [4]
Wikidata
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60S ribosomal protein L7 is a protein that in humans is encoded by the RPL7 gene.^[5][6][7]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus sub-motif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

Interactions

RPL7 has been shown to interact with ZNF7.^[8] It interacts with HIV-1 Gag protein through Zinc Finger of HIV-1 Gag.^[9]