8-Bromotheophylline
Clinical data
Other namesBromotheophylline
Identifiers
  • 8-Bromo-1,3-dimethyl-7H-purine-2,6-dione
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.030.757 Edit this at Wikidata
Chemical and physical data
FormulaC7H7BrN4O2
Molar mass259.063 g·mol−1
3D model (JSmol)
  • CN1C2=C(C(=O)N(C1=O)C)NC(=N2)Br
  • InChI=1S/C7H7BrN4O2/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h1-2H3,(H,9,10)
  • Key:SKTFQHRVFFOHTQ-UHFFFAOYSA-N

8-Bromotheophylline is a xanthine diuretic drug. It is the main active ingredient in pamabrom where it is sold as an over-the-counter medication in combination with paracetamol, among other analgesics, to treat dysmenorrhea.[1][2] It is also an adenosine receptor A1 antagonist.[3]

See also

References

  1. ^ Ortiz MI, Murguía-Cánovas G, Vargas-López LC, Silva R, González-de la Parra M (October 2016). "Naproxen, paracetamol and pamabrom versus paracetamol, pyrilamine and pamabrom in primary dysmenorrhea: a randomized, double-blind clinical trial". Medwave. 16 (9): e6587. doi:10.5867/medwave.2016.09.6587. PMID 27813503.
  2. ^ Ortiz MI (September 2010). "Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment". European Journal of Obstetrics, Gynecology, and Reproductive Biology. 152 (1): 73–77. doi:10.1016/j.ejogrb.2010.04.015. PMID 20478651.
  3. ^ Jacobson KA, Shi D, Gallo-Rodriguez C, Manning M, Müller C, Daly JW, et al. (September 1993). "Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors". Journal of Medicinal Chemistry. 36 (18): 2639–2644. doi:10.1021/jm00070a007. PMID 8410976.
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