ACVR2B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACVR2B, ACTRIIB, ActR-IIB, HTX4, activin A receptor type 2B
External IDsOMIM: 602730 MGI: 87912 HomoloGene: 863 GeneCards: ACVR2B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001106

NM_007397
NM_001313757

RefSeq (protein)

NP_001097

NP_001300686
NP_031423

Location (UCSC)Chr 3: 38.45 – 38.49 MbChr 9: 119.23 – 119.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene.[5][6][7] ACVR2B is an activin type 2 receptor.

Function

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.[7]

Interactions

ACVR2B has been shown to interact with ACVR1B[8][9] and SYNJ2BP.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114739Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061393Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hildén K, Tuuri T, Erämaa M, Ritvos O (May 1994). "Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor". Blood. 83 (8): 2163–70. doi:10.1182/blood.V83.8.2163.2163. PMID 8161782.
  6. ^ Ishikawa S, Kai M, Murata Y, Tamari M, Daigo Y, Murano T, Ogawa M, Nakamura Y (July 1998). "Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene". J. Hum. Genet. 43 (2): 132–4. doi:10.1007/s100380050054. PMID 9621519.
  7. ^ a b "Entrez Gene: ACVR2B activin A receptor, type IIB".
  8. ^ Attisano L, Wrana JL, Montalvo E, Massagué J (March 1996). "Activation of signalling by the activin receptor complex". Mol. Cell. Biol. 16 (3): 1066–73. doi:10.1128/mcb.16.3.1066. PMC 231089. PMID 8622651.
  9. ^ De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ (May 1996). "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors". Exp. Cell Res. 224 (2): 323–34. doi:10.1006/excr.1996.0142. PMID 8612709.
  10. ^ Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". J. Biol. Chem. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.

Further reading