ACY1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q7L
Identifiers
Aliases	ACY1, ACY-1, ACY1D, HEL-S-5, aminoacylase 1
External IDs	OMIM: 104620 MGI: 87913 HomoloGene: 110440 GeneCards: ACY1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.2 Start 51,983,340 bp[1] End 51,989,197 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 57.49 cM Start 106,310,180 bp[2] End 106,315,518 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum right lobe of liver kidney renal cortex right adrenal gland rectum left adrenal gland right lobe of thyroid gland left lobe of thyroid gland prostate Top expressed in proximal tubule yolk sac kidney jejunum duodenum crypt of lieberkuhn of small intestine left lobe of liver ectoderm otic placode intestinal villus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding hydrolase activity metallopeptidase activity metal ion binding aminoacylase activity identical protein binding Cellular component cytoplasm cytosol extracellular exosome Biological process xenobiotic metabolic process cellular amino acid metabolic process metabolism proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 95 109652 Ensembl ENSG00000243989 ENSMUSG00000023262 UniProt Q03154 Q99JW2 RefSeq (mRNA) NM_001198898 NM_000666 NM_001198895 NM_001198896 NM_001198897 NM_001276442 NM_025371 RefSeq (protein) NP_000657 NP_001185824 NP_001185825 NP_001185826 NP_001185827 NP_001263371 NP_079647 Location (UCSC) Chr 3: 51.98 – 51.99 Mb Chr 9: 106.31 – 106.32 Mb PubMed search [3] [4]
Wikidata
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Aminoacylase-1 is an enzyme that in humans is encoded by the ACY1 gene.^[5][6][7]

Function

Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.^[7]