ADCY7
Identifiers
Aliases	ADCY7, AC7, adenylate cyclase 7
External IDs	OMIM: 600385 MGI: 102891 HomoloGene: 866 GeneCards: ADCY7
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q12.1 Start 50,246,137 bp[1] End 50,318,135 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C3|8 43.06 cM Start 88,999,031 bp[2] End 89,056,590 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood appendix secondary oocyte lymph node bone marrow cells spleen gallbladder placenta upper lobe of left lung Top expressed in ascending aorta aortic valve Paneth cell carotid body blood substantia nigra spleen conjunctival fornix condyle calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function adenylate cyclase activity ATP binding phosphorus-oxygen lyase activity metal ion binding nucleotide binding lyase activity guanylate cyclase activity Cellular component integral component of membrane membrane plasma membrane guanylate cyclase complex, soluble intracellular anatomical structure integral component of plasma membrane Biological process renal water homeostasis intracellular signal transduction cellular response to ethanol cellular response to glucagon stimulus cyclic nucleotide biosynthetic process maternal process involved in female pregnancy cGMP biosynthetic process signal transduction adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cAMP biosynthetic process adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of adaptive immune response cellular response to lithium ion negative regulation of cytokine production involved in inflammatory response activation of adenylate cyclase activity activation of protein kinase A activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 113 11513 Ensembl ENSG00000121281 ENSMUSG00000031659 UniProt P51828 P51829 RefSeq (mRNA) NM_001114 NM_001286057 NM_001037723 NM_001037724 NM_001109756 NM_007406 RefSeq (protein) NP_001105 NP_001272986 NP_001032812 NP_001032813 NP_001103226 NP_031432 Location (UCSC) Chr 16: 50.25 – 50.32 Mb Chr 8: 89 – 89.06 Mb PubMed search [3] [4]
Wikidata
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Adenylyl cyclase type 7 is an enzyme that in humans is encoded by the ADCY7 gene.^[5][6]

Function

This gene encodes a membrane-bound adenylyl cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.^[6]