ADH1C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HT0, 1U3W
Identifiers
Aliases	ADH1C, ADH3, alcohol dehydrogenase 1C (class I), gamma polypeptide
External IDs	OMIM: 103730 MGI: 87921 HomoloGene: 73888 GeneCards: ADH1C
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q23 Start 99,336,497 bp[1] End 99,352,746 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 G3|3 64.16 cM Start 137,966,752 bp[2] End 137,996,459 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa right lobe of liver duodenum rectum palpebral conjunctiva bronchial epithelial cell pylorus gallbladder parietal pleura body of stomach Top expressed in conjunctival fornix left lung lobe left colon adrenal gland left lobe of liver gallbladder seminal vesicula corneal stroma lacrimal gland duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity zinc ion binding alcohol dehydrogenase (NAD+) activity metal ion binding NAD-retinol dehydrogenase activity alcohol dehydrogenase activity, zinc-dependent Cellular component cytoplasm nucleoplasm cytosol plasma membrane Biological process ethanol oxidation retinol metabolic process retinoic acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 126 11522 Ensembl ENSG00000248144 ENSMUSG00000074207 UniProt P00326 P00329 RefSeq (mRNA) NM_000669 NM_007409 RefSeq (protein) NP_000660 NP_031435 Location (UCSC) Chr 4: 99.34 – 99.35 Mb Chr 3: 137.97 – 138 Mb PubMed search [3] [4]
Wikidata
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Alcohol dehydrogenase 1C is an enzyme that in humans is encoded by the ADH1C gene.^[5]

Function

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol (beverage alcohol), retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibit high activity for ethanol oxidation and play a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.^[6]