Clinical data
Routes of
By mouth
Drug classNMDA receptor modulator
CAS Number

AGN-241751 is an orally active small-molecule NMDA receptor modulator which is under development for the treatment of major depressive disorder (MDD).[1][2] It was originated by Naurex and was acquired by Allergan from Aptinyx in May 2018.[1][2] Allergan (previously Naurex) is also developing the NMDA receptor modulators rapastinel (GLYX-13; intravenous) and apimostinel (NRX-1074, AGN-241660; oral) for the treatment of MDD.[3][4][5] Like apimostinel, AGN-241751 is intended as an oral follow-up compound to rapastinel.[2][6] As of May 2018, the drug is in phase I clinical trials.[1][2]

See also


  1. ^ a b c "Research programme: NMDA receptor modulators - Allergan - AdisInsight".
  2. ^ a b c d Inc., Aptinyx. "Allergan Exercises Option to Acquire Compound from Aptinyx Discovery Platform Under Ongoing Research Collaboration".
  3. ^ Vazquez GH, Camino S, Tondo L, Baldessarini RJ (2018). "Potential Novel Treatments for Bipolar Depression: Ketamine, Fatty Acids, Anti-inflammatory Agents, and Probiotics". CNS Neurol Disord Drug Targets. 16 (8): 858–869. doi:10.2174/1871527316666170728165648. PMID 28758582.
  4. ^ "Rapastinel - Allergan - AdisInsight".
  5. ^ "Apimostinel - Allergan - AdisInsight".
  6. ^ "J&J therapy for suicidal depressives 'a breakthrough', says FDA". PMLive. 17 August 2016.