AH-494
Identifiers
  • 3‐(1‐ethyl‐1H‐imidazol‐5‐yl)‐1H‐indole‐5‐carboxamide
PubChem CID
ChemSpider
Chemical and physical data
FormulaC14H14N4O
Molar mass254.293 g·mol−1
3D model (JSmol)
  • CCn1cncc1-c1c[nH]c2ccc(cc12)C(N)=O
  • InChI=1S/C14H14N4O/c1-2-18-8-16-7-13(18)11-6-17-12-4-3-9(14(15)19)5-10(11)12/h3-8,17H,2H2,1H3,(H2,15,19)
  • Key:RXDHCCKYQJNUFV-UHFFFAOYSA-N

AH-494 is a potent and selective, water-soluble full agonist at the 5HT7 serotonin receptor. It is a close derivative of the known chemical probe 5-Carboxamidotryptamine, as well as of the more lipophilic indole-imidazoles: AGH-107 and AGH-192. It has been shown to exhibit favorable ADMET profile in in vitro assays.[1]

See also

References

  1. ^ Latacz G, Hogendorf AS, Hogendorf A, Lubelska A, Wierońska JM, Woźniak M, Cieślik P, Kieć-Kononowicz K, Handzlik J, Bojarski AJ (September 2018). "Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists". MedChemComm. 9 (11): 1882–1890. doi:10.1039/c8md00313k. PMC 6256855. PMID 30568756.
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