The AHFS DI is one of several compendiums[1] approved by the Social Security Act (Section 1861(t)(2)(B)(ii)(I)) as a source of off-label anti-cancer drug use.[2][3] It was originally published in 1959 as the American Hospital Formulary Service (AHFS) by the American Society of Health-System Pharmacists.
It is also the only one left of the originally authorized compendiums.[4]