AKAP9
Identifiers
AliasesAKAP9, AKAP-9, AKAP350, AKAP450, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO, A-kinase anchoring protein 9
External IDsOMIM: 604001 HomoloGene: 17517 GeneCards: AKAP9
Orthologs
SpeciesHumanMouse
Entrez

10142

n/a

Ensembl

ENSG00000127914

n/a

UniProt

Q99996
Q6PJH3

n/a

RefSeq (mRNA)

NM_005751
NM_147166
NM_147171
NM_147185
NM_001379277

n/a

RefSeq (protein)

NP_005742
NP_671714
NP_001366206
NP_005742.4
NP_671714.1

n/a

Location (UCSC)Chr 7: 91.94 – 92.11 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

A-kinase anchor protein 9 is a protein that in humans is encoded by the AKAP9 gene.[3][4][5] AKAP9 is also known as Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP) or AKAP350 or AKAP450 [6]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in many isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3.[5]

Interactions

AKAP9 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127914 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Lin JW, Wyszynski M, Madhavan R, Sealock R, Kim JU, Sheng M (Apr 1998). "Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1". J Neurosci. 18 (6): 2017–27. doi:10.1523/JNEUROSCI.18-06-02017.1998. PMC 6792910. PMID 9482789.
  4. ^ Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK, Sheng M, Scott JD (Jul 1999). "Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex". Science. 285 (5424): 93–6. doi:10.1126/science.285.5424.93. PMID 10390370.
  5. ^ a b "Entrez Gene: AKAP9 A kinase (PRKA) anchor protein (yotiao) 9".
  6. ^ Ong ST, Chalasani ML, Fazil MH, Prasannan P, Kizhakeyil A, Wright GD, Kelleher D, Verma NK (Mar 2018). "Centrosome- and Golgi-Localized Protein Kinase N-Associated Protein Serves As a Docking Platform for Protein Kinase A Signaling and Microtubule Nucleation in Migrating T-Cells". Front. Immunol. 9 (397): 397. doi:10.3389/fimmu.2018.00397. PMC 5837996. PMID 29545805.
  7. ^ a b Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (Sep 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
  8. ^ a b Larocca MC, Shanks RA, Tian L, Nelson DL, Stewart DM, Goldenring JR (Jun 2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus". Mol. Biol. Cell. 15 (6): 2771–81. doi:10.1091/mbc.E03-10-0757. PMC 420101. PMID 15047863.
  9. ^ Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS (Jan 2002). "Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel". Science. 295 (5554): 496–9. Bibcode:2002Sci...295..496M. doi:10.1126/science.1066843. PMID 11799244. S2CID 6153394.
  10. ^ a b Takahashi M, Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y (Jun 1999). "Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus". J. Biol. Chem. 274 (24): 17267–74. doi:10.1074/jbc.274.24.17267. PMID 10358086.
  11. ^ Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. Bibcode:2003PNAS..100.4445A. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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