AKT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X18
Identifiers
Aliases	AKT3, MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2, AKT serine/threonine kinase 3
External IDs	OMIM: 611223 MGI: 1345147 HomoloGene: 55904 GeneCards: AKT3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q43-q44 Start 243,488,233 bp[1] End 243,851,079 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H4 Start 176,847,639 bp[2] End 177,085,769 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence popliteal artery sural nerve islet of Langerhans smooth muscle tissue right coronary artery gastric mucosa prefrontal cortex left coronary artery Top expressed in facial motor nucleus secondary oocyte ganglionic eminence substantia nigra ascending aorta medial dorsal nucleus Region I of hippocampus proper aortic valve superior frontal gyrus piriform cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein serine/threonine kinase activity protein binding ATP binding kinase activity Cellular component intracellular anatomical structure membrane nucleus cytoplasm Biological process protein phosphorylation intracellular signal transduction peptidyl-serine phosphorylation mitochondrial genome maintenance signal transduction phosphorylation positive regulation of TOR signaling positive regulation of cell size brain morphogenesis homeostasis of number of cells within a tissue positive regulation of endothelial cell proliferation positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis positive regulation of cell migration involved in sprouting angiogenesis positive regulation of vascular endothelial cell proliferation positive regulation of artery morphogenesis negative regulation of cellular senescence Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10000 23797 Ensembl ENSG00000117020 ENSG00000275199 ENSMUSG00000019699 UniProt Q9Y243 Q9WUA6 RefSeq (mRNA) NM_001206729 NM_005465 NM_181690 NM_001370074 NM_011785 RefSeq (protein) NP_001193658 NP_005456 NP_859029 NP_001357003 NP_035915 Location (UCSC) Chr 1: 243.49 – 243.85 Mb Chr 1: 176.85 – 177.09 Mb PubMed search [3] [4]
Wikidata
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RAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT3 gene.^[5][6]

Function

The protein encoded by this gene is a member of the AKT subfamily of serine/threonine protein kinases. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.^[7] Mice lacking Akt3 have a normal glucose metabolism (no diabetes), have approximately normal body weight, but have a 25% reduction in brain mass. Incidentally, Akt3 is highly expressed in the brain.

Interactions

AKT3 has been shown to interact with Protein kinase Mζ.^[8]