ALG6
Identifiers
Aliases	ALG6, CDG1C, alpha-1,3-glucosyltransferase, ALG6 alpha-1,3-glucosyltransferase
External IDs	OMIM: 604566 MGI: 2444031 HomoloGene: 6920 GeneCards: ALG6
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 63,367,575 bp[1] End 63,438,553 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C6 Start 99,603,901 bp[2] End 99,651,697 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte monocyte rectum tibial nerve skin of abdomen retinal pigment epithelium spleen right uterine tube lymph node body of pancreas Top expressed in yolk sac duodenum jejunum hepatobiliary system liver ileum placenta colon muscle tissue proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity hexosyltransferase activity glucosyltransferase activity dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity glycosyltransferase activity dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum Biological process protein glycosylation dolichol-linked oligosaccharide biosynthetic process oligosaccharide-lipid intermediate biosynthetic process protein N-linked glycosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29929 320438 Ensembl ENSG00000088035 ENSMUSG00000073792 UniProt Q9Y672 Q3TAE8 RefSeq (mRNA) NM_013339 NM_001081264 RefSeq (protein) NP_037471 NP_001074733 Location (UCSC) Chr 1: 63.37 – 63.44 Mb Chr 4: 99.6 – 99.65 Mb PubMed search [3] [4]
Wikidata
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Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase is an enzyme that in humans is encoded by the ALG6 gene.^[5][6][7]

Function

This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic.^[7]