|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||441.531 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
AM-1221 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 0.28 nM at CB2 and 52.3 nM at the CB1 receptor, giving it around 180 times selectivity for CB2. The 2-methyl and 6-nitro groups on the indole ring both tend to increase CB2 affinity while generally reducing affinity at CB1, explaining the high CB2 selectivity of AM-1221. However, despite this relatively high selectivity for CB2, its CB1 affinity is still too strong to make it useful as a truly selective CB2 agonist, so the related compound AM-1241 is generally preferred for research purposes.
In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as AM-1221 are Schedule I Controlled Substances.
It's illegal supply, trade, sell, distribute, import or transport the pharmaceutical drug under the Psychoactive Substances Act 2016 which was inforce on May26th 2016.