|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||458.343 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
AM-2233 is a drug that acts as a highly potent full agonist for the cannabinoid receptors, with a Ki of 1.8 nM at CB1 and 2.2 nM at CB2 as the active (R) enantiomer. It was developed as a selective radioligand for the cannabinoid receptors and has been used as its 131I derivative for mapping the distribution of the CB1 receptor in the brain. AM-2233 was found to fully substitute for THC in rats, with a potency lower than that of JWH-018 but higher than WIN 55,212-2.
It is notable for inducing tinnitus, though the reasons for this are unclear and may provide valuable insight into tinnitus research.
As of October 2015 AM-2233 is a controlled substance in China.