ARHGEF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Z0Q
Identifiers
Aliases	ARHGEF3, GEF3, STA3, XPLN, Rho guanine nucleotide exchange factor 3
External IDs	OMIM: 612115 MGI: 1918954 HomoloGene: 41329 GeneCards: ARHGEF3
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.3 Start 56,727,418 bp[1] End 57,079,329 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 A3|14 16.09 cM Start 26,836,856 bp[2] End 27,125,868 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glomerulus metanephric glomerulus endothelial cell Brodmann area 23 germinal epithelium middle temporal gyrus oral cavity parietal pleura optic nerve islet of Langerhans Top expressed in pontine nuclei cerebellar vermis right lung right lung lobe subiculum olfactory tubercle left lung lobe blood medial vestibular nucleus dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol intracellular anatomical structure Biological process regulation of Rho protein signal transduction intracellular signal transduction regulation of small GTPase mediated signal transduction Rho protein signal transduction positive regulation of apoptotic process G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50650 71704 Ensembl ENSG00000163947 ENSMUSG00000021895 UniProt Q9NR81 Q91X46 RefSeq (mRNA) NM_001128615 NM_001128616 NM_001289698 NM_019555 NM_001377407 NM_001377408 NM_001377409 NM_001377410 NM_001377411 NM_001377412 NM_001377413 NM_001377414 NM_001377415 NM_001289686 NM_001289687 NM_001289688 NM_027871 RefSeq (protein) NP_001122087 NP_001122088 NP_001276627 NP_062455 NP_001364336 NP_001364337 NP_001364338 NP_001364339 NP_001364340 NP_001364341 NP_001364342 NP_001364343 NP_001364344 NP_001276615 NP_001276616 NP_001276617 NP_082147 Location (UCSC) Chr 3: 56.73 – 57.08 Mb Chr 14: 26.84 – 27.13 Mb PubMed search [3] [4]
Wikidata
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Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene.^[5]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to the NET1A protein.^[5]

Interactions

ARHGEF3 has been shown to interact with RHOA^[6] and RHOB.^[6]