ATP12A
Identifiers
AliasesATP12A, ATP1AL1, #945, HK, ATPase H+/K+ transporting non-gastric alpha2 subunit, H-K-ATPase
External IDsOMIM: 182360 MGI: 1926943 HomoloGene: 68197 GeneCards: ATP12A
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001676
NM_001185085

NM_138652

RefSeq (protein)

NP_001172014
NP_001667

NP_619593

Location (UCSC)Chr 13: 24.68 – 24.71 MbChr 14: 56.6 – 56.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium-transporting ATPase alpha chain 2 is a protein that in humans is encoded by the ATP12A gene.[5][6][7][8]

Function

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075673 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022229 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "ATP12A - Potassium-transporting ATPase alpha chain 2 - Homo sapiens (Human) - ATP12A gene & protein". www.uniprot.org. Retrieved 9 April 2022.
  6. ^ a b "Entrez Gene: ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide".
  7. ^ Sverdlov VE, Kostina MB, Modyanov NN (March 1996). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794.
  8. ^ Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U (February 1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.

Further reading