ATP5F1B
Identifiers
AliasesATP5F1B, ATPMB, ATPSB, HEL-S-271, ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide, ATP synthase F1 subunit beta, ATP5B
External IDsOMIM: 102910 MGI: 107801 HomoloGene: 1273 GeneCards: ATP5F1B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001686

NM_016774

RefSeq (protein)

NP_001677

NP_058054

Location (UCSC)Chr 12: 56.64 – 56.65 MbChr 10: 128.08 – 128.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP synthase F1 subunit beta, mitochondrial is an enzyme that in humans is encoded by the ATP5F1B gene.[5][6]

Function

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110955 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025393 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Neckelmann N, Warner CK, Chung A, Kudoh J, Minoshima S, Fukuyama R, Maekawa M, Shimizu Y, Shimizu N, Liu JD (Jan 1990). "The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression". Genomics. 5 (4): 829–43. doi:10.1016/0888-7543(89)90125-0. PMID 2687158.
  6. ^ a b "Entrez Gene: ATP5F1B ATP synthase F1 subunit beta".

Further reading