ATP5MC1
Identifiers
Aliases	ATP5MC1, ATP5A, ATP5G, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9), ATP synthase membrane subunit c locus 1, ATP5G1
External IDs	OMIM: 603192 MGI: 107653 HomoloGene: 38017 GeneCards: ATP5MC1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,892,765 bp[1] End 48,895,871 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 95,959,678 bp[2] End 95,966,496 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum left ventricle gastrocnemius muscle body of stomach prefrontal cortex right lobe of thyroid gland right ventricle islet of Langerhans anterior pituitary left lobe of thyroid gland Top expressed in morula lip superior frontal gyrus yolk sac esophagus neural tube proximal tubule lens stomach cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding transporter activity proton transmembrane transporter activity protein binding proton-transporting ATP synthase activity, rotational mechanism Cellular component proton-transporting ATP synthase complex, coupling factor F(o) membrane integral component of membrane mitochondrion mitochondrial membranes proton-transporting two-sector ATPase complex, proton-transporting domain mitochondrial proton-transporting ATP synthase complex mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrial inner membrane Biological process ion transport ATP biosynthetic process ATP synthesis coupled proton transport cristae formation mitochondrial ATP synthesis coupled proton transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 516 11951 Ensembl ENSG00000159199 ENSMUSG00000006057 UniProt P05496 Q9CR84 RefSeq (mRNA) NM_005175 NM_001002027 NM_001161419 NM_007506 RefSeq (protein) NP_001002027 NP_005166 NP_001154891 NP_031532 Location (UCSC) Chr 17: 48.89 – 48.9 Mb Chr 11: 95.96 – 95.97 Mb PubMed search [3] [4]
Wikidata
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The ATP5MC1 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.^[5][6]

Function

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[6]