ATP5MF
Identifiers
Aliases	ATP5MF, ATP5JL, ATP synthase, H+ transporting, mitochondrial Fo complex subunit F2, ATP5J2, ATP synthase membrane subunit f
External IDs	MGI: 1927558 HomoloGene: 3594 GeneCards: ATP5MF
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 99,448,475 bp[1] End 99,466,186 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 145,120,508 bp[2] End 145,128,872 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex left ventricle ganglionic eminence anterior pituitary right adrenal gland gastrocnemius muscle left adrenal gland islet of Langerhans rectum cingulate gyrus Top expressed in atrioventricular valve endocardial cushion intercostal muscle myocardium of ventricle cardiac muscles digastric muscle extraocular muscle soleus muscle thoracic diaphragm sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase activity transmembrane transporter activity Cellular component integral component of membrane mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrial proton-transporting ATP synthase complex extracellular exosome nucleus membrane proton-transporting ATP synthase complex, coupling factor F(o) nucleoplasm mitochondrion Biological process ATP metabolic process mitochondrial ATP synthesis coupled proton transport ion transport ATP biosynthetic process cristae formation transport proton transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9551 57423 Ensembl ENSG00000241468 ENSMUSG00000038690 UniProt P56134 P56135 RefSeq (mRNA) NM_004889 NM_001003713 NM_001003714 NM_001039178 NM_001190353 NM_001190354 NM_020582 RefSeq (protein) NP_001003713 NP_001003714 NP_001034267 NP_004880 NP_065607 Location (UCSC) Chr 7: 99.45 – 99.47 Mb Chr 5: 145.12 – 145.13 Mb PubMed search [3] [4]
Wikidata
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The ATP5MF gene^[5][6] encodes the ATP synthase subunit f, mitochondrial enzyme in humans.

Function

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.^[6]