DMAC2L
Identifiers
Aliases	DMAC2L, ATPW, FB, HSU79253, ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B), ATP5S, distal membrane arm assembly complex 2 like, distal membrane arm assembly component 2 like
External IDs	MGI: 1915305 HomoloGene: 12232 GeneCards: DMAC2L
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q21.3 Start 50,312,324 bp[1] End 50,335,558 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 69,771,724 bp[2] End 69,791,434 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right uterine tube endothelial cell triceps brachii muscle oocyte thoracic diaphragm right ventricle human penis muscle of leg gastrocnemius muscle Top expressed in interventricular septum spermatid right ventricle spermatocyte sternocleidomastoid muscle digastric muscle myocardium of ventricle triceps brachii muscle temporal muscle proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function proton transmembrane transporter activity metal ion binding Cellular component mitochondrion membrane proton-transporting ATP synthase complex, coupling factor F(o) mitochondrial inner membrane Biological process ion transport ATP biosynthetic process cristae formation proton transmembrane transport mitochondrial ATP synthesis coupled proton transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27109 68055 Ensembl ENSG00000125375 ENSMUSG00000054894 UniProt Q99766 Q9CRA7 RefSeq (mRNA) NM_001003803 NM_001003805 NM_015684 NM_001370605 NM_001382507 NM_001382509 NM_001382510 NM_026536 NM_001361690 NM_001361691 RefSeq (protein) NP_001003803 NP_001003805 NP_056499 NP_001357534 NP_001369436 NP_001369438 NP_001369439 NP_080812 NP_001348619 NP_001348620 Location (UCSC) Chr 14: 50.31 – 50.34 Mb Chr 12: 69.77 – 69.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ATP synthase subunit s, mitochondrial is an enzyme that in humans is encoded by the ATP5S gene.^[5][6][7]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]