ATP6V0B
Identifiers
Aliases	ATP6V0B, ATP6F, HATPL, VMA16, ATPase H+ transporting V0 subunit b
External IDs	OMIM: 603717 MGI: 1890510 HomoloGene: 2986 GeneCards: ATP6V0B
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.1 Start 43,974,487 bp[1] End 43,978,295 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D1 Start 117,741,523 bp[2] End 117,744,530 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary monocyte prefrontal cortex body of pancreas blood periodontal fiber right adrenal gland left adrenal gland islet of Langerhans cingulate gyrus Top expressed in facial motor nucleus superior frontal gyrus entorhinal cortex anterior horn of spinal cord cerebellar cortex barrel cortex Region I of hippocampus proper retinal pigment epithelium yolk sac lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function proton transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism transporter activity Cellular component vacuole vacuolar membrane membrane vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain phagocytic vesicle membrane endosome membrane proton-transporting two-sector ATPase complex, proton-transporting domain integral component of membrane Biological process regulation of macroautophagy vacuolar acidification ion transmembrane transport insulin receptor signaling pathway ion transport transferrin transport proton transmembrane transport phagosome acidification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 533 114143 Ensembl ENSG00000117410 ENSMUSG00000033379 UniProt Q99437 Q91V37 RefSeq (mRNA) NM_004047 NM_001039457 NM_001294333 NM_033617 RefSeq (protein) NP_001034546 NP_001281262 NP_004038 NP_291095 Location (UCSC) Chr 1: 43.97 – 43.98 Mb Chr 4: 117.74 – 117.74 Mb PubMed search [3] [4]
Wikidata
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V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.^[5][6]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits, plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d.

Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes, or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain, and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.^[6]