ATP6V0D2
Identifiers
Aliases	ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2, ATP6D2, VMA6, ATPase H+ transporting V0 subunit d2
External IDs	OMIM: 618072 MGI: 1924415 HomoloGene: 72090 GeneCards: ATP6V0D2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.3 Start 85,987,323 bp[1] End 86,154,225 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A3 Start 19,876,841 bp[2] End 19,922,605 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney amniotic fluid renal medulla rectum tibia lower lobe of lung lymph node appendix islet of Langerhans minor salivary gland Top expressed in submandibular gland body of femur parotid gland calvaria kidney right lung right lung lobe epithelium of stomach superior cervical ganglion cochlea More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding proton transmembrane transporter activity P-type proton-exporting transporter activity proton-transporting ATPase activity, rotational mechanism Cellular component proton-transporting V-type ATPase, V0 domain endosome phagocytic vesicle membrane membrane apical plasma membrane vacuolar proton-transporting V-type ATPase complex endosome membrane extracellular exosome lysosomal membrane early endosome plasma membrane proton-transporting V-type ATPase complex Biological process insulin receptor signaling pathway transferrin transport ion transport ion transmembrane transport regulation of macroautophagy phagosome acidification vacuolar transport vacuolar acidification transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 245972 242341 Ensembl ENSG00000147614 ENSMUSG00000028238 UniProt Q8N8Y2 Q80SY3 RefSeq (mRNA) NM_152565 NM_175406 RefSeq (protein) NP_689778 NP_780615 Location (UCSC) Chr 8: 85.99 – 86.15 Mb Chr 4: 19.88 – 19.92 Mb PubMed search [3] [4]
Wikidata
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ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 is a protein in humans that is encoded by the ATP6V0D2 gene. ^[5] It is part of proton pumps in the plasma membranes of osteoclasts and aids with extracellular acidification in bone resorption. ^[6]