ATP6V1C1
Identifiers
Aliases	ATP6V1C1, ATP6C, ATP6D, VATC, Vma5, ATPase H+ transporting V1 subunit C1
External IDs	OMIM: 603097 MGI: 1913585 HomoloGene: 1281 GeneCards: ATP6V1C1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.3 Start 103,021,063 bp[1] End 103,073,051 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 38,662,177 bp[2] End 38,692,690 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm prefrontal cortex islet of Langerhans superior frontal gyrus middle temporal gyrus Brodmann area 23 pons Brodmann area 9 parietal lobe postcentral gyrus Top expressed in hippocampus proper yolk sac hypothalamus superior frontal gyrus cerebellar cortex olfactory bulb proximal tubule secondary oocyte kidney neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity proton-transporting ATPase activity, rotational mechanism protein binding proton transmembrane transporter activity P-type proton-exporting transporter activity Cellular component cytoplasm proton-transporting V-type ATPase, V1 domain cytosol plasma membrane proton-transporting two-sector ATPase complex apical part of cell lysosomal membrane extracellular exosome cytoplasmic vesicle vacuolar proton-transporting V-type ATPase, V1 domain Biological process insulin receptor signaling pathway transferrin transport ion transport ion transmembrane transport regulation of macroautophagy phagosome acidification transport proton transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 528 66335 Ensembl ENSG00000155097 ENSMUSG00000022295 UniProt P21283 Q9Z1G3 RefSeq (mRNA) NM_001695 NM_001007254 NM_025494 RefSeq (protein) NP_001686 NP_079770 Location (UCSC) Chr 8: 103.02 – 103.07 Mb Chr 15: 38.66 – 38.69 Mb PubMed search [3] [4]
Wikidata
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V-type proton ATPase subunit C 1 is an enzyme that in humans is encoded by the ATP6V1C1 gene.^[5][6][7]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.^[7]

In melanocytic cells ATP6V1C1 gene expression may be regulated by MITF.^[8]