ATP6V1G3
Identifiers
Aliases	ATP6V1G3, ATP6G3, Vma10, ATPase H+ transporting V1 subunit G3
External IDs	OMIM: 618071 MGI: 2450548 HomoloGene: 13630 GeneCards: ATP6V1G3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q31.3 Start 198,523,222 bp[1] End 198,540,945 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 138,201,476 bp[2] End 138,217,200 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney minor salivary gland lymph node ganglionic eminence thymus bone marrow prostate placenta spleen liver Top expressed in kidney renal cortex skin zone of skin limb More reference expression data BioGPS n/a
Gene ontology Molecular function ATPase binding P-type proton-exporting transporter activity ATPase-coupled transmembrane transporter activity Cellular component cytosol plasma membrane vacuolar proton-transporting V-type ATPase complex Biological process proton transmembrane transport insulin receptor signaling pathway ion transmembrane transport ion transport transferrin transport phagosome acidification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127124 338375 Ensembl ENSG00000151418 ENSG00000263014 ENSMUSG00000026394 UniProt Q96LB4 Q8BMC1 RefSeq (mRNA) NM_133262 NM_133326 NM_001320218 NM_001376861 NM_001376862 NM_001376863 NM_177397 RefSeq (protein) NP_001307147 NP_573569 NP_579872 NP_001363790 NP_001363791 NP_001363792 NP_796371 Location (UCSC) Chr 1: 198.52 – 198.54 Mb Chr 1: 138.2 – 138.22 Mb PubMed search [3] [4]
Wikidata
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V-type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene.^[5][6]

Function

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.^[6]