AFM
Identifiers
Aliases	AFM, ALB2, ALBA, ALF, afamin
External IDs	OMIM: 104145 MGI: 2429409 HomoloGene: 881 GeneCards: AFM
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 73,481,745 bp[1] End 73,504,001 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 90,666,791 bp[2] End 90,701,402 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver kidney tubule kidney glomerulus metanephric glomerulus tibialis anterior muscle renal medulla fundus body of pancreas body of stomach Top expressed in left lobe of liver kidney proximal straight tubule renal pelvis renal calyx sexually immature organism gallbladder ureter medullary collecting duct ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vitamin E binding protein binding Cellular component extracellular region blood microparticle extracellular exosome extracellular space Biological process vitamin transport transport protein transport protein stabilization protein transport within extracellular region Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 173 280662 Ensembl ENSG00000079557 ENSMUSG00000029369 UniProt P43652 O89020 RefSeq (mRNA) NM_001133 NM_145146 RefSeq (protein) NP_001124 NP_660128 Location (UCSC) Chr 4: 73.48 – 73.5 Mb Chr 5: 90.67 – 90.7 Mb PubMed search [3] [4]
Wikidata
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Afamin is a protein that in humans is encoded by the AFM gene.^[5][6]

Function

This gene is a member of the albumin gene family, which comprises four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream.^[6]