Aggressive digital papillary adenocarcinoma
Other namesDigital papillary adenocarcinoma and papillary adenoma[1]
Digital papillary adenocarcinoma or aggressive digital papillary adenoma
SpecialtyDermatology/Oncology

Aggressive digital papillary adenocarcinoma, also known as digital papillary adenocarcinoma and papillary adenoma is a cutaneous condition characterized by an aggressive malignancy involving the digit between the nailbed and the distal interphalangeal joint spaces.[2]: 670 

Signs and symptoms

Aggressive digital papillary adenocarcinoma typically appears as a painless solitary mass on the plantar surface of the feet or palmer surface of the hands.[3]

Diagnosis

Histologically, the tumor exhibits a mixed tubuloalveolar and papillary pattern, focal squamous metaplasia, fibrocollagenous stroma, and a grenz zone.[4]

The sweat gland adenoid cystic carcinoma, mucinous eccrine carcinoma, and apocrine adenocarcinoma are included in the differential diagnosis.[5]

Treatment

As a first-line surgical strategy, wide local excision with clear resection of margins is advised rather than proximal amputation, and there is currently insufficient evidence to justify the routine use of adjuvant chemotherapy or radiotherapy.[3]

Epidemiology

Aggressive digital papillary adenocarcinoma primarily affects men and is usually diagnosed between the ages of 50 and 70.[6]

See also

References

  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
  3. ^ a b Jabbour, Austin J.; Tangoren, Ibrahim A.; Kanik, Andrew B. (2021-08-06). "Digital Papillary Adenocarcinoma: Case of a Rare Malignant Cutaneous Tumor of the Eccrine Sweat Gland". Case Reports in Dermatology. 13 (2): 422–427. doi:10.1159/000518442. ISSN 1662-6567. PMC 8436639. PMID 34594201.
  4. ^ Jih, Debra M.; Elenitsas, Rosalie; Vittorio, Carmela C.; Berkowitz, Allen R.; Seykora, John T. (2001). "Aggressive Digital Papillary Adenocarcinoma". The American Journal of Dermatopathology. 23 (2). Ovid Technologies (Wolters Kluwer Health): 154–157. doi:10.1097/00000372-200104000-00014. ISSN 0193-1091. PMID 11285414.
  5. ^ Kraus, Armin; Altmann, Silke; Damert, Hans-Georg; Infanger, Manfred; Klausenitz, Stephanie (2015). "Aggressive digital papillary adenocarcinoma – a rare malignant tumor of the sweat glands: two case reports and a review of the literature". Clinical, Cosmetic and Investigational Dermatology. 8. Informa UK Limited: 143–146. doi:10.2147/ccid.s71323. ISSN 1178-7015. PMC 4386778. PMID 25848311.
  6. ^ Kasimo, Betty A.; Akello, Vivian; Yahaya, James J. (2021). "Digital papillary adenocarcinoma: A case report". Clinical Case Reports. 9 (9). Wiley. doi:10.1002/ccr3.4814. ISSN 2050-0904. PMC 8436734. PMID 34532052.

Further reading

External links

Classification
Skin cancer of the epidermis
Category