Albert Hofmann
Hofmann in 1993
Born	(1906-01-11)11 January 1906 Baden, Aargau, Switzerland
Died	29 April 2008(2008-04-29) (aged 102) Burg im Leimental, Basel-Landschaft, Switzerland
Alma mater	University of Zürich (PhD)
Occupations	Chemist author
Employer	Sandoz
Known for	Discovery of LSD-25. Isolating, naming and synthesizing psilocybin and psilocin, as well as synthesizing various analogs thereof.
Spouse	Anita Hofmann (died 2007)
Children	4
Relatives	Gustav Guanella (brother-in-law)
Awards	Scheele Award

Albert Hofmann (11 January 1906 – 29 April 2008) was a Swiss chemist known for being the first to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD). Hofmann's team also isolated, named and synthesized the principal psychedelic mushroom compounds psilocybin and psilocin.^[1] He authored more than 100 scientific articles and numerous books, including LSD: Mein Sorgenkind (LSD: My Problem Child).^[2] In 2007, he shared first place with Tim Berners-Lee on a list of the 100 greatest living geniuses published by The Daily Telegraph newspaper.^[3]

Early life and education

Albert Hofmann was born in Baden, Switzerland, on 11 January 1906.^[4][2] He was the first of four children to factory toolmaker Adolf Hofmann and Elisabeth (née Schenk) and was baptized Protestant.^[5] When his father became ill, Hofmann obtained a position as a commercial apprentice in concurrence with his studies. At age 20, Hofmann began his chemistry degree at the University of Zürich, finishing three years later, in 1929. Owing to his father's low income, Albert's godfather paid for his education. Hofmann's main interest was the chemistry of plants and animals, and he later conducted important research on the chemical structure of the common animal substance chitin, for which he received his doctorate with distinction in 1929.^[6]

Career

Of his decision to pursue a career as a chemist, Hofmann provided insight during a speech he delivered to the 1996 Worlds of Consciousness Conference in Heidelberg, Germany:

One often asks oneself what roles planning and chance play in the realization of the most important events in our lives. [...] This [career] decision was not easy for me. I had already taken a Latin matricular exam, and therefore a career in the humanities stood out most prominently in the foreground. Moreover, an artistic career was tempting. In the end, however, it was a problem of theoretical knowledge which induced me to study chemistry, which was a great surprise to all who knew me. Mystical experiences in childhood, in which Nature was altered in magical ways, had provoked questions concerning the essence of the external, material world, and chemistry was the scientific field which might afford insights into this.^[7]

Discovery of LSD

In 1929, Hofmann became an employee of the pharmaceutical/chemical department of Sandoz Laboratories (now a subsidiary of Novartis) as a coworker of Arthur Stoll, founder and director of the pharmaceutical department.^[8] He began studying the medicinal plant Drimia maritima (squill) and the fungus ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals. His main contribution was to elucidate the chemical structure of the common nucleus of the Scilla glycosides (an active principle of Mediterranean squill).^[8] While researching lysergic acid derivatives, Hofmann first synthesized LSD on 16 November 1938.^[9] The main intention of the synthesis was to obtain a respiratory and circulatory stimulant (analeptic) with no effects on the uterus in analogy to nikethamide (which is also a diethylamide) by introducing this functional group to lysergic acid. It was set aside for five years, until 16 April 1943, when Hofmann reexamined it and discovered its powerful effects.^[10] He described what he felt as being:

... affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated[-]like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away.^[11]

Three days later, on 19 April 1943, Hofmann intentionally ingested 250 micrograms of LSD, which he thought would represent a prudently safe, small amount, but was in fact a strong dose. At first, his trip was not pleasant, as people appeared to morph into fantastic creatures, office furniture moved and shifted like living entities, and he felt possessed by otherworldly forces.

April 19 is now widely known as "Bicycle Day", because as Hofmann began to feel LSD's effects, he tried to ride to the safety of his home on his bike. This was the first intentional LSD trip in history.

Hofmann's research with LSD influenced several psychiatrists, including Ronald A. Sandison, who developed its use in psychotherapy. Sandison's treatment at Powick Hospital in England received international acclaim.^[12]

Hofmann continued to take small doses of LSD throughout his life, and always hoped to find a use for it. In his memoir, he emphasized it as a "sacred drug": "I see the true importance of LSD in the possibility of providing material aid to meditation aimed at the mystical experience of a deeper, comprehensive reality."^[13]

Further research

It gave me an inner joy, an open mindedness, a gratefulness, open eyes and an internal sensitivity for the miracles of creation. ... I think that in human evolution it has never been as necessary to have this substance LSD. It is just a tool to turn us into what we are supposed to be.

— Albert Hofmann, Speech on 100th birthday^[14]

Hofmann later discovered 4-Acetoxy-DET, a hallucinogenic tryptamine. He first synthesized 4-AcO-DET in 1958 in the Sandoz lab. Hofmann became director of Sandoz's natural products department and continued studying hallucinogenic substances found in Mexican mushrooms and other plants used by aboriginal people there. This led to the isolation and synthesis of psilocybin, the active agent of many "magic mushrooms".^[15] Hofmann also became interested in the seeds of the Mexican morning glory species Turbina corymbosa, called ololiuqui by natives. He was surprised to find the active compound of ololiuqui, ergine (LSA, lysergic acid amide), to be closely related to LSD.

In 1962, Hofmann and his wife Anita Hofmann traveled to Mexico to search for the psychoactive plant "Ska Maria Pastora" (Leaves of Mary the Shepherdess), later known as Salvia divinorum. He was able to obtain samples of it, but never succeeded in identifying its active compound, which has since been identified as salvinorin A. In 1963, Hofmann attended the annual convention of the World Academy of Arts and Sciences (WAAS) in Stockholm.

Later years

Interviewed shortly before his 100th birthday, Hofmann called LSD "medicine for the soul" and was frustrated by its worldwide prohibition. "It was used very successfully for ten years in psychoanalysis," he said, adding that the drug was misused by the counterculture of the 1960s, and then criticized unfairly by the political establishment of the day. He conceded that it could be dangerous if misused, because a relatively high dose of 500 micrograms has an extremely powerful psychoactive effect, especially if administered to a first-time user without adequate supervision.^[16]

In December 2007, Swiss medical authorities allowed psychotherapist Peter Gasser to perform psychotherapeutic experiments on patients with terminal-stage cancer and other terminal diseases. Completed in 2011, these represent the first study of the therapeutic effects of LSD on humans in 35 years; other studies had examined the drug's effects on consciousness and body.^[17] Hofmann acclaimed the study and reiterated his belief in LSD's therapeutic benefits.^[18] In 2008, he wrote to Steve Jobs, asking him to support this research; it is not known whether Jobs responded.^[19] The Multidisciplinary Association for Psychedelic Studies (MAPS) has supported psychoanalytic research using LSD, carrying on Hofmann's legacy and setting the groundwork for future studies.^[20]

Hofmann was a longtime friend and correspondent of German author and entomologist Ernst Jünger, whom he met in 1949. Jünger experimented with LSD with Hofmann; in 1970, Jünger published a book of his experiences taking several types of drugs, Approaches: Drugs and Intoxication (German: Annäherungen. Drogen und Rausch).^[21]

Archives

After retiring from Sandoz in 1971, Hofmann was allowed to take his papers and research home. He gave his archive to the Albert Hofmann Foundation, a Los Angeles–based nonprofit, but the documents mostly sat in storage for years. The archives were sent to the San Francisco area in 2002 to be digitized, but that process was never completed. In 2013, the archive was sent to the Institute of Medical History in Bern, Switzerland, where it is being organized. According to Beat Bächi, who has been researching the estate at the Institute as part of an SNSF research project, LSD as a drug was something for the cultural elite in Hofmann's opinion.^[22][23]

Death

Hofmann died at the age of 102 from a heart attack, on 29 April, 2008, in Switzerland.^[24]

Honors and awards

The Swiss Federal Institute of Technology (ETH Zurich) honored him with the title DSc (honoris causa) in 1969 together with Gustav Guanella, his brother-in-law. In 1971 the Swedish Pharmaceutical Association granted him the Scheele Award, which commemorates the skills and achievements of the Swedish Pomerania chemist and pharmacist Carl Wilhelm Scheele.^[25]

Publications

Books

• Hofmann, Albert (1964). Die Mutterkornalkaloide (in German). Stuttgart: Ferdinand Enke Verlag.
• Hofmann, Albert (2020). LSD - mein Sorgenkind [LSD — My Problem Child] (PDF) (in German) (11th ed.). Stuttgart: Klett-Cotta. ISBN 978-3-608-94618-5.
• Einsichten und Ausblicke (Essays). Basel: Sphinx Verlag (1986); ISBN 3-85914-633-5.

Public speaking

• "Transcript of a Special Videotaped Message From Albert Hofmann to the Participants at the April 16 & 17, 1993 Symposiums on the 50th Anniversary of his Discovery of LSD." MAPS | Multidisciplinary Association for Psychedelic Studies, vol. 4, no. 2 (Summer 1993), p. 56.