ALKBH1
Identifiers
Aliases	ALKBH1, ABH, ABH1, ALKBH, alkB, hABH, alkB homolog 1, histone H2A dioxygenase
External IDs	OMIM: 605345 MGI: 2384034 HomoloGene: 4393 GeneCards: ALKBH1
EC number	4.2.99.18
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 77,672,404 bp[1] End 77,708,023 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D2 Start 87,472,610 bp[2] End 87,490,787 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte endothelial cell right ventricle jejunal mucosa gastrocnemius muscle embryo ganglionic eminence mucosa of urinary bladder left ventricle Top expressed in Paneth cell primitive streak spermatocyte hand yolk sac ascending aorta hair follicle otolith organ thymus utricle More reference expression data BioGPS n/a
Gene ontology Molecular function methylcytosine dioxygenase activity dioxygenase activity metal ion binding catalytic activity lyase activity chemoattractant activity oxidoreductase activity ferrous iron binding tRNA binding 2-oxoglutarate-dependent dioxygenase activity DNA-N1-methyladenine dioxygenase activity tRNA demethylase activity class I DNA-(apurinic or apyrimidinic site) endonuclease activity DNA-(apurinic or apyrimidinic site) endonuclease activity Cellular component mitochondrion nucleus Biological process negative regulation of neuron apoptotic process cell differentiation DNA dealkylation involved in DNA repair placenta development neuron migration in utero embryonic development cellular response to DNA damage stimulus oxidative demethylation developmental growth regulation of gene expression RNA repair DNA demethylation positive chemotaxis metabolism neuron projection development DNA repair regulation of translation tRNA wobble cytosine modification regulation of translational initiation regulation of translational elongation oxidative single-stranded DNA demethylation regulation of mitochondrial translation tRNA demethylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8846 211064 Ensembl ENSG00000100601 ENSMUSG00000079036 UniProt Q13686 P0CB42 RefSeq (mRNA) NM_001039506 NM_006020 NM_001102565 RefSeq (protein) NP_006011 NP_001096035 Location (UCSC) Chr 14: 77.67 – 77.71 Mb Chr 12: 87.47 – 87.49 Mb PubMed search [3] [4]
Wikidata
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AlkB homolog 1, histone H2A dioxygenase is a protein that in humans is encoded by the ALKBH1 gene. ^[5]

Function

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008].