TXLNA
Identifiers
AliasesTXLNA, IL14, TXLN, IL-14, taxilin alpha
External IDsOMIM: 608676 MGI: 105968 HomoloGene: 14062 GeneCards: TXLNA
Orthologs
SpeciesHumanMouse
Entrez

200081

109658

Ensembl

ENSG00000084652

ENSMUSG00000053841

UniProt

P40222

Q6PAM1

RefSeq (mRNA)

NM_175852
NM_001376857
NM_001376858
NM_001376859

NM_001005506
NM_001199695

RefSeq (protein)

NP_787048
NP_001363786
NP_001363787
NP_001363788

NP_001005506
NP_001186624

Location (UCSC)Chr 1: 32.18 – 32.2 MbChr 4: 129.52 – 129.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene.[5][6][7]

Interleukin-14 is a cytokine that controls the growth and proliferation of both normal and cancerous B cells.[8] This molecule was also recently designated taxilin.[9] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.

Gene

In murine models, two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β.[10] The il14 locus is near the gene for LCK on chromosome 1 in humans.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000084652 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053841 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. 319 (3): 936–43. doi:10.1016/j.bbrc.2004.05.073. PMID 15184072.
  6. ^ Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex". Biochem. Biophys. Res. Commun. 311 (4): 797–802. doi:10.1016/j.bbrc.2003.10.069. PMID 14623251.
  7. ^ "Entrez Gene: TXLNA taxilin alpha".
  8. ^ Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ (July 1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6330–4. Bibcode:1993PNAS...90.6330A. doi:10.1073/pnas.90.13.6330. PMC 46922. PMID 8327514.
  9. ^ Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H (January 2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells". Genes Cells. 8 (1): 17–28. doi:10.1046/j.1365-2443.2003.00612.x. PMID 12558796.
  10. ^ Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL (October 2006). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676–86. doi:10.4049/jimmunol.177.8.5676. PMID 17015757. S2CID 86324456.

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