The conference began as the Show-Me Conference in 1986, then changed to its current name in 1994, reflecting that its footprint had expanded beyond Missouri.
2008 - Stephens College joined the American Midwest, effective in the 2008-09 academic year.
2009 - Park re-joined back to the American Midwest, effective in the 2009-10 academic year.
2011 - McKendree left the American Midwest and the NAIA to join the NCAA Division II ranks as an Division II Independent (which would later join the Great Lakes Valley Conference (GLVC), effective beginning the 2012-13 academic year), effective after the 2010-11 academic year.
2014 - Mid-Continent left the American Midwest after spending one season, as the school announced that it would close, effective after the 2013-14 academic year.
2020 - Three institutions left the American Midwest to join their respective new home primary conferences: Freed–Hardeman to join the Mid-South Conference, Lindenwood–Belleville announced that it would close, and Park to join the Heart of America Athletic Conference (HAAC), all effective after the 2019-20 academic year.
2020 - Marian (Ind.) left the American Midwest as an associate member for men's wrestling, effective after the 2019-20 academic year.
2020 - Lincoln College of Illinois joined the American Midwest as an associate member for men's wrestling, effective in the 2020-21 academic year.
2022 - Lyon announced that it will leave the American Midwest and the NAIA to join the NCAA Division III ranks and the St. Louis Intercollegiate Athletic Conference (SLIAC), effective after the 2022-23 academic year.[1] Currently Lyon will compete in NCAA Division III as a provisional full independent for 2022-23.
2022 - Cottey College joined the American Midwest from the Independent ranks, effective in the 2022-23 academic year.
Member schools
Current members
The American Midwest currently has 11 full members, all but one are private schools:
Departing members are highlighted in pink.
^The Benedictine–Springfield men's and women's basketball teams joined the American Midwest a year after becoming a full member for other sports (2012–13).
^Currently known as Fontbonne University since 2002.