Amitriptyline/perphenazine (Duo-Vil, Etrafon, Triavil, Triptafen) is a formulation that contains the tricyclic antidepressant amitriptyline and the medium-potency typical (first-generation) antipsychotic, perphenazine. In the United States amitriptyline/perphenazine is marketed by Mylan Pharmaceuticals Inc. and Remedy Repack Inc.
In the United States amitriptyline/perphenazine is indicated for the treatment of patients with:
- Moderate-severe anxiety and/or agitation and depression
- Depression and anxiety in association with chronic physical disease
- Schizophrenia with prominent depressive symptoms
Binding affinities (Ki[nM]; for human cloned receptors when available)
(Amitriptyline's active metabolite)
||It is this and its NET-inhibiting action is believed to give amitriptyline its |
||Binding for human brain receptors had to be substituted in amitriptyline (AMI)|
and nortriptyline's (NOR) cases
||Binding for cloned rat receptors had to be substituted for AMI & NOR. Binding|
to this receptor is believed to be what gives the newer (atypical) antipsychotics,
clozapine, quetiapine, olanzapine, ziprasidone, risperidone, sertindole and
zotepine their lower extrapyramidal side effect (EPS) liability.
||(Binding) As above. This action is believed to be partly responsible for the lower|
EPS liability of newer antipsychotics and also responsible for their higher weight
gain liability compared to most typical antipsychotics.
||Cloned rat receptor was substituted for NOR's binding.
||Cloned rat receptor was substituted for AMI.
||Human brain receptors were substituted for AMI and NOR.
||Human receptors (their source was undefined) had to be substituted for AMI.
||This receptor is at least partly responsible for the sedating effects of these three|
drugs and hence this combination product. Possibly also partly responsible for
their weight gain liability.
||This is the main receptor responsible for the anticholinergic side effects |
||This receptor is believed to be partly responsible for the metabolic adverse|
effects of the atypical antipsychotics.
||All three values are for binding to the guinea pig brain receptors.