| Amyderýa Nature Reserve | |
|---|---|
  | |
| Location | Lebap Province,  Turkmenistan |
| Coordinates | 39°39′N 62°51′E / 39.650°N 62.850°E |
| Area | 495 km² |
| Established | 1982 |
Amyderýa Nature Reserve (Turkmen: Amyderýa goraghanasy) is a nature reserve (zapovednik) of north-eastern Turkmenistan.
Established in 1982 to protect part of the Amu Darya River, it is located in the north-east of Lebap Province and covers an area of 495 km2.
It also incorporates one sanctuary:
- Kelif Sanctuary - established in 1970.