Andrew David Hamilton Wyllie FMedSci FRS[1] (1944 – 26 May 2022)[2] was a Scottish pathologist. In 1972, while working with electron microscopes at the University of Aberdeen he realised the significance of natural cell death.[3][4] He and his colleagues John Kerr and Alastair Currie called this process apoptosis, from the use of this word in an ancient Greek poem to mean "falling off" (like leaves falling from a tree).[3][4] He completed postdoctoral training in Cambridge University and became Professor of Experimental Pathology at the University of Edinburgh Medical School in 1992. He left Edinburgh for a chair at Cambridge in 1998 where he continued to lecture to undergraduate medical and natural sciences students.[5] His works have contributed to the understanding of apoptosis in health and in disease. Apoptosis is used during early development to eliminate unwanted cells; for example, those between the fingers of a developing hand. In adults, apoptosis is used to rid the body of cells that have been damaged beyond repair. Apoptosis also plays a critical role in preventing cancer. If apoptosis is for some reason prevented, it can lead to uncontrolled cell division and the subsequent development of a tumour.

After retirement, Wyllie was succeeded in his role as Head of the Department of Pathology at Cambridge by Geoffrey L. Smith in October 2011.[6]

Career and awards

References

  1. ^ Arends, Mark J.; Stanley, Margaret (2023). "Andrew David Hamilton Wyllie. 24 January 1944—26 May 2022". Biographical Memoirs of Fellows of the Royal Society. 76.
  2. ^ Tributes paid to Professor of Pathology who discovered that cells die
  3. ^ a b Agency for Science, Technology and Research. "Prof Andrew H. Wyllie – Lecture abstract". Archived from the original on 13 November 2007. Retrieved 30 March 2007.
  4. ^ a b Kerr, John F. R.; Wyllie, Andrew; Currie, Alastair (August 1972). "Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics". British Journal of Cancer. 26 (4): 239–257. doi:10.1038/bjc.1972.33. ISSN 0007-0920. PMC 2008650. PMID 4561027.
  5. ^ Tributes paid to Professor of Pathology who discovered that cells die
  6. ^ Cambridge Fund for the Prevention of Disease; Department of Pathology (21 February 2012). Graves, Nicola (ed.). "Welcome Professor Geoffrey L Smith, FRS" (PDF). Pathology News. No. 3. University of Cambridge. p. 3. Archived from the original (PDF) on 20 May 2012. Retrieved 21 June 2012.
  7. ^ a b c d e Agency for Science, Technology and Research. "Biographical notes – Prof A H Wyllie". Archived from the original on 16 November 2007. Retrieved 30 March 2007.
  8. ^ "Gairdner celebration winds up". University of Toronto. 25 October 1999. Archived from the original on 1 November 2007. Retrieved 4 November 2007.

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