Ann M. Valentine
EducationUniversity of Virginia (BS); Massachusetts Institute of Technology (PhD)
Scientific career
FieldsBioinorganic chemistry
InstitutionsYale University, Temple University
ThesisBioinorganic Hydrocarbon Oxidation: Mechanistic and Kinetic Studies of the Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath) (1998)
Doctoral advisorStephen J. Lippard
Other academic advisorsTimothy L. Macdonald, Stephen J. Benkovic
WebsiteThe Valentine Lab

Ann M. Valentine is an American bioinorganic chemist whose research focuses on biomineralization, the uptake and transport of metals and their medical applications in areas such as cancer research.[1] She has received awards including the 2014 AICChemical Pioneer Award "for her outstanding contributions towards advancing the science of chemistry and impacting the chemical profession"[2] and the 2009 Paul D. Saltman Award for Metals in Biology for "outstanding contributions to the field of metals in biology" and "groundbreaking work on the structures and reactions of complexes containing titanium."[3]

Education

Valentine earned a Bachelor of Science in chemistry from the University of Virginia in 1993. As an undergraduate, she researched aluminum inhibition of magnesium-dependent enzymes with Timothy L. Macdonald. She studied with Stephen J. Lippard at the Massachusetts Institute of Technology and earned her PhD in 1998.

Career

From 1998-2001, Valentine worked with Stephen J. Benkovic as a postdoctoral fellow at Pennsylvania State University.[4] She published on the topics of enzyme kinetics,[5] metallo-beta-lactamase,[6] and the mechanics of replisome and primase in DNA replication.[7][8]

In 2001, Valentine joined the chemistry faculty of Yale University.[9] During her years there, she was able to begin research into the biological role of titanium, a question which she had long found intriguing. Valentine had become interested in the element early in her graduate career: in the early 1990s, titanium was not recognized as important in bioinorganic chemistry, but was believed by some (including her advisor) to be a candidate for future investigation.[10]

In 2011, Valentine became an associate professor at Temple University where she specializes in environmental, material, and medicinal aspects of inorganic and biological chemistry.[4] Her research group focuses on bioinorganic chemistry, especially nicatransferrin, Ti4+ ions, and biotitanification.[11]

Outreach and mentorship

Valentine has participated in the Philadelphia Area Girls Enjoying Science (PAGES) and Temple Minority Access to Research Careers (MARC) programs. Via the Temple Teaching and Learning Center, she has acted as a mentor for students in high-attrition courses.[2]

Awards and honors

References

  1. ^ Withers, Neil. "Reactions – Ann Valentine". The Sceptical Chymist. Nature. Retrieved 24 August 2016.
  2. ^ a b c Chemical Pioneer Award, American Institute of Chemists website, http://www.theaic.org/awards_chem_pioneer.html (accessed 23 August 2016).
  3. ^ a b Taylor Muzzin, Suzanne (March 6, 2009). "Chemist Honored for Studies on Biological Activities of Titanium". Yale News. Retrieved 1 September 2016.
  4. ^ a b Ann M. Valentine, Department of Chemistry, Temple University website, https://chem.cst.temple.edu/valentine.html (accessed 23 August 2016).
  5. ^ Benkovic, Stephen J.; Valentine, Ann M. (2003). "Enzyme Mechanisms". In Meyers, Robert A. (ed.). Encyclopedia of Physical Science and Technology (3rd ed.). Academic Press. pp. 627–39. doi:10.1016/B0-12-227410-5/00231-3. ISBN 978-0-12-227410-7.
  6. ^ Wang, Zhigang; Fast, Walter; Valentine, Ann M; Benkovic, Stephen J (1999). "Metallo-β-lactamase: structure and mechanism". Current Opinion in Chemical Biology. 3 (5): 614–22. doi:10.1016/S1367-5931(99)00017-4. PMID 10508665.
  7. ^ Benkovic, Stephen J.; Valentine, Ann M.; Salinas, Frank (2001). "Replisome-Mediated DNA Replication". Annual Review of Biochemistry. 70 (1): 181–208. doi:10.1146/annurev.biochem.70.1.181. PMID 11395406.
  8. ^ Valentine, Ann M.; Ishmael, Faoud T.; Shier, Vincent K.; Benkovic, Stephen J. (2001). "A Zinc Ribbon Protein in DNA Replication: Primer Synthesis and Macromolecular Interactions by the Bacteriophage T4 Primase". Biochemistry. 40 (50): 15074–85. doi:10.1021/bi0108554. PMID 11735390.
  9. ^ Ann M. Valentine, Department of Chemistry, University of Virginia website, http://chem.virginia.edu/contact-us/chemistry-alumni/uva-bs-graduates/ann-m-valentine/ Archived 2015-09-14 at the Wayback Machine (accessed 23 August 2016).
  10. ^ Valentine, Ann M. (2015). "Exploring a Role for Titanium in Bioinorganic Chemistry". The Chemist. 88 (2).
  11. ^ Research, The Valentine Lab, https://valentinelab.com/research/ (accessed 23 August 2016).
  12. ^ a b "Ann M. Valentine" (PDF). Temple University. Retrieved 1 September 2016.
  13. ^ Buettner, Katherine M.; Valentine, Ann M. (14 March 2012). "Bioinorganic Chemistry of Titanium". Chemical Reviews. 112 (3): 1863–1881. doi:10.1021/cr1002886. PMID 22074443.
  14. ^ "Award Abstract #0348960 CAREER: Metal Transport by the Primitive Monolobal Transferrin". National Science Foundation. Retrieved 1 September 2016.
  15. ^ Tinoco, A. D.; Peterson, C. W.; Lucchese, B.; Doyle, R. P.; Valentine, A. M. (20 February 2008). "On the evolutionary significance and metal-binding characteristics of a monolobal transferrin from Ciona intestinalis". Proceedings of the National Academy of Sciences. 105 (9): 3268–3273. Bibcode:2008PNAS..105.3268T. doi:10.1073/pnas.0705037105. PMC 2265155. PMID 18287008.
  16. ^ "Research Corporation 2002 Annual Report" (PDF). Research Corporation for Science Advancement. January 1, 2002. p. 29.
  17. ^ "Honors Profs Announced as CST Faculty Award Winners". Honors Program. Retrieved 19 July 2022.
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