ANXA11
Identifiers
Aliases	ANXA11, ANX11, CAP50, annexin A11, CAP-50, ALS23, IBMWMA
External IDs	OMIM: 602572 MGI: 108481 HomoloGene: 22759 GeneCards: ANXA11
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.3 Start 80,150,889 bp[1] End 80,205,572 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 A3|14 15.06 cM Start 25,842,580 bp[2] End 25,887,228 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva left ventricle blood bronchial epithelial cell ascending aorta upper lobe of left lung right coronary artery body of stomach cavity of mouth rectum Top expressed in placenta quadriceps femoris muscle colon muscle tissue skeletal muscle tissue ileum jejunum urinary bladder duodenum lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding S100 protein binding calcium-dependent protein binding phosphatidylethanolamine binding protein binding MHC class II protein complex binding calcium-dependent phospholipid binding RNA binding Cellular component cytoplasm nuclear envelope membrane melanosome spindle nucleoplasm midbody azurophil granule specific granule phagocytic vesicle extracellular exosome cytoskeleton nucleus cytosol collagen-containing extracellular matrix Biological process cell division response to calcium ion phagocytosis cell cycle cytokinetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 311 11744 Ensembl ENSG00000122359 ENSMUSG00000021866 UniProt P50995 P97384 RefSeq (mRNA) NM_001157 NM_001278407 NM_001278408 NM_001278409 NM_145868 NM_145869 NM_013469 RefSeq (protein) NP_001148 NP_001265336 NP_001265337 NP_001265338 NP_665875 NP_665876 NP_038497 Location (UCSC) Chr 10: 80.15 – 80.21 Mb Chr 14: 25.84 – 25.89 Mb PubMed search [3] [4]
Wikidata
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Annexin A11 is a protein that in humans is encoded by the ANXA11 gene.^[5][6][7]

Function

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Transcript variants encoding the same isoform have been identified.^[7]

Interactions

ANXA11 has been shown to interact with PDCD6^[8] and ALG2.^[9]

Clinical significance

It is shown that over-expression of the ANXA11 is involved in apoptotic alterations in schizophrenia and contribute to pathomechanisms of this disorder.^[10]