ANXA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W7B, 1XJL, 2HYU, 2HYV, 2HYW, 4DRW, 4FTG, 4HRH
Identifiers
Aliases	ANXA2, ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV, annexin A2
External IDs	OMIM: 151740 MGI: 88246 HomoloGene: 20857 GeneCards: ANXA2
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.2 Start 60,347,134 bp[1] End 60,402,883 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 C|9 38.58 cM Start 69,360,902 bp[2] End 69,399,077 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell amniotic fluid synovial joint visceral pleura parietal pleura oral cavity hair follicle islet of Langerhans palpebral conjunctiva trigeminal ganglion Top expressed in corneal stroma calvaria dermis belly cord conjunctival fornix right lung lobe skin of abdomen cervix ankle skin of back More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipase inhibitor activity calcium ion binding S100 protein binding phospholipase A2 inhibitor activity calcium-dependent protein binding protease binding cytoskeletal protein binding protein binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding cadherin binding involved in cell-cell adhesion RNA binding identical protein binding bone sialoprotein binding molecular function regulator phosphatidylserine binding calcium channel activity virion binding voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels Cellular component vesicle cytosol endosome membrane late endosome membrane melanosome ruffle plasma membrane lipid droplet myelin sheath adaxonal region Schmidt-Lanterman incisure PCSK9-AnxA2 complex macropinosome basement membrane cell surface lysosomal membrane basolateral plasma membrane cell cortex midbody early endosome perinuclear region of cytoplasm sarcolemma extrinsic component of plasma membrane extracellular exosome nucleus extracellular space azurophil granule lumen cytoplasm membrane raft extracellular matrix extracellular region protein-containing complex collagen-containing extracellular matrix Biological process negative regulation of low-density lipoprotein particle receptor catabolic process positive regulation of protein phosphorylation protein heterotetramerization fibrinolysis body fluid secretion collagen fibril organization positive regulation of fibroblast proliferation response to thyroid hormone positive regulation of binding positive regulation of vesicle fusion membrane raft assembly angiogenesis vesicle budding from membrane osteoclast development cell-cell adhesion negative regulation of catalytic activity positive regulation of receptor recycling neutrophil degranulation positive regulation of low-density lipoprotein particle clearance positive regulation of low-density lipoprotein particle receptor binding positive regulation of low-density lipoprotein receptor activity positive regulation of receptor-mediated endocytosis involved in cholesterol transport negative regulation of formation of structure involved in a symbiotic process positive regulation of vacuole organization interleukin-12-mediated signaling pathway protein localization to plasma membrane growth plate cartilage development regulation of plasminogen activation biomineral tissue development positive regulation of chondrocyte differentiation positive regulation by host of viral process regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport endocardial cell differentiation calcium ion transmembrane transport positive regulation of viral life cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 302 12306 Ensembl ENSG00000182718 ENSMUSG00000032231 UniProt P07355 P07356 RefSeq (mRNA) NM_001002857 NM_001002858 NM_001136015 NM_004039 NM_007585 RefSeq (protein) NP_001002857 NP_001002858 NP_001129487 NP_004030 NP_031611 Location (UCSC) Chr 15: 60.35 – 60.4 Mb Chr 9: 69.36 – 69.4 Mb PubMed search [3] [4]
Wikidata
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Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene.^[5]

Annexin 2 is involved in diverse cellular processes such as cell motility (especially that of the epithelial cells), linkage of membrane-associated protein complexes to the actin cytoskeleton, endocytosis, fibrinolysis, ion channel formation, and cell matrix interactions. It is a calcium-dependent phospholipid-binding protein whose function is to help organize exocytosis of intracellular proteins to the extracellular domain. Annexin II is a pleiotropic protein meaning that its function is dependent on place and time in the body.

Gene

The ANXA2 gene, located at 15q22.2, has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[6]

Function

This protein is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption.^[6] Epigenetic regulation of Annexin A2 has been identified as a key determinant of mesenchymal transformation in brain tumors.^[7] Maternal deficiency of the ANXA2 gene contributes to shallow decidual invasion by placental cytotrophoblast cells. These findings highlight the maternal contribution to the pathogenesis of severe preeclampsia.^[8]

Annexin A2 has been proposed to function inside the cell in sorting of endosomes and outside the cell in anticoagulant reactions.

Interactions

Annexin A2 has been shown to interact with Prohibitin,^[9] CEACAM1,^[10] S100A10,^[11][12] PCNA,^[13] complement Factor H,^[14] and a number of viral factors including the HPV16 minor capsid protein L2.^[15][16]