ANXA4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZOC
Identifiers
Aliases	ANXA4, ANX4, HEL-S-274, PIG28, ZAP36, P32.5, PAP-II, PP4-X, annexin A4
External IDs	OMIM: 106491 MGI: 88030 HomoloGene: 68164 GeneCards: ANXA4
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 69,644,425 bp[1] End 69,827,112 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 D1|6 37.75 cM Start 86,713,822 bp[2] End 86,770,566 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell gallbladder jejunal mucosa duodenum body of pancreas islet of Langerhans bronchial epithelial cell germinal epithelium visceral pleura Achilles tendon Top expressed in Paneth cell jejunum crypt of lieberkuhn of small intestine gastric mucosa epithelium of stomach ileum pyloric antrum mucous cell of stomach intestinal villus duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipase inhibitor activity calcium ion binding calcium-dependent protein binding NF-kappaB binding protein binding identical protein binding calcium-dependent phospholipid binding heparin binding chondroitin sulfate binding Cellular component cytoplasm nuclear membrane vesicle membrane plasma membrane cell surface perinuclear region of cytoplasm extracellular exosome nucleus cytosol collagen-containing extracellular matrix Biological process Notch signaling pathway epithelial cell differentiation regulation of transcription by RNA polymerase II negative regulation of apoptotic process negative regulation of NF-kappaB transcription factor activity signal transduction negative regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 307 11746 Ensembl ENSG00000196975 ENSMUSG00000029994 UniProt P09525 P97429 RefSeq (mRNA) NM_001153 NM_001320698 NM_001320700 NM_001320702 NM_001365496 NM_013471 NM_001331120 RefSeq (protein) NP_001144 NP_001307627 NP_001307629 NP_001307631 NP_001352425 NP_001318049 NP_038499 Location (UCSC) Chr 2: 69.64 – 69.83 Mb Chr 6: 86.71 – 86.77 Mb PubMed search [3] [4]
Wikidata
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Annexin A4 is a protein that in humans is encoded by the ANXA4 gene.^[5][6]

Function

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells.^[6]