Antistaphylococcal penicillins[1] are a chemical compound. They are a class of Beta lactam antibiotics used to treat infections caused by bacteria.[2]

History

Penicillin resistance in Staphylococcus aureus[3] appeared very soon after penicillin entered general clinical use in 1943, and the mechanism of resistance was the production of β-lactamase. Modification of the penicillin molecule so that it was resistant to being broken down by β-lactamase was able to temporarily overcome this problem.[citation needed]

These compounds became known as antistaphylococcal penicillins.[when?] The first of these compounds was methicillin, which is no longer in general use. The range of these penicillins available in each country is very different, and the reasons for this are historical.[citation needed]

Penicillin family

See also

References

  1. ^ Alan R. Hauser (6 March 2012). Antibiotic Basics for Clinicians: The ABCs of Choosing the Right Antibacterial Agent. Lippincott Williams & Wilkins. p. 25. ISBN 978-1-4511-1221-4. Retrieved 6 August 2017.
  2. ^ M.I. Page (6 December 2012). The Chemistry of β-Lactams. Springer Science & Business Media. p. 103. ISBN 978-94-011-2928-2. Retrieved 6 August 2017.
  3. ^ Smolin, Gilbert; Foster, Charles Stephen; Dimitri T., Azar (2005). Claes H. Dohlman (ed.). Smolin and Thoft's The Cornea: Scientific Foundations and Clinical Practice. Lippincott Williams & Wilkins. p. 261. ISBN 978-0-7817-4206-1. Retrieved 6 August 2017.
  4. ^ Anand Ramachandran (2007). Pharmacology Recall. Lippincott Williams & Wilkins. p. 376. ISBN 978-0-7817-5562-7. Retrieved 6 August 2017.


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