APLNR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPLNR, AGTRL1, APJ, APJR, HG11, apelin receptor
External IDsOMIM: 600052 MGI: 1346086 HomoloGene: 3784 GeneCards: APLNR
Orthologs
SpeciesHumanMouse
Entrez

187

23796

Ensembl

ENSG00000134817

ENSMUSG00000044338

UniProt

P35414

Q9WV08

RefSeq (mRNA)

NM_005161

NM_011784

RefSeq (protein)

NP_005152

NP_035914

Location (UCSC)Chr 11: 57.23 – 57.24 MbChr 2: 84.97 – 84.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The Apelin Receptor (APLNR, also known as APJ) is a G protein-coupled receptor.[5] APLNR possesses two endogenous ligands which are APELIN[6][7][8] and ELABELA.[9][10] The structure of APLNR was resolved in 2017[11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134817 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044338 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, et al. (December 1993). "A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11". Gene. 136 (1–2): 355–60. doi:10.1016/0378-1119(93)90495-O. PMID 8294032.
  6. ^ Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, et al. (October 1998). "Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor". Biochemical and Biophysical Research Communications. 251 (2): 471–6. doi:10.1006/bbrc.1998.9489. PMID 9792798.
  7. ^ Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, et al. (January 2000). "Characterization of apelin, the ligand for the APJ receptor". Journal of Neurochemistry. 74 (1): 34–41. doi:10.1046/j.1471-4159.2000.0740034.x. PMID 10617103. S2CID 6548112.
  8. ^ Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H, et al. (September 2002). "Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility". Circulation Research. 91 (5): 434–40. doi:10.1161/01.RES.0000033522.37861.69. PMID 12215493.
  9. ^ Chng SC, Ho L, Tian J, Reversade B (December 2013). "ELABELA: a hormone essential for heart development signals via the apelin receptor". Developmental Cell. 27 (6): 672–80. doi:10.1016/j.devcel.2013.11.002. PMID 24316148.
  10. ^ Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, et al. (February 2014). "Toddler: an embryonic signal that promotes cell movement via Apelin receptors". Science. 343 (6172): 1248636. doi:10.1126/science.1248636. PMC 4107353. PMID 24407481.
  11. ^ Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, et al. (June 2017). "Structural Basis for Apelin Control of the Human Apelin Receptor". Structure. 25 (6): 858–866.e4. doi:10.1016/j.str.2017.04.008. PMID 28528775.

Further reading

External links


Cell surface receptor: G protein-coupled receptors
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