Artavasdes I Mamikonian (Armenian: Արտավազդ Ա Մամիկոնյան) was an Armenian sparapet of the Kingdom of Armenia, and the oldest ancestor of the Mamikonian family. He lived at the end of the 3rd and early 4th centuries. According to Christian Settipani, he married a daughter of the Iberian ruler Amazasp III, and had two sons, Vache Mamikonian and Hamazasp, whose offspring would play an important role in the politics of Armenia.

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